World Mediated Cell

07 November 2024

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Humoral vs Cell-mediated Immunity

Humoral immunity and cell-mediated immunity are two forms of adaptive immune responses that allow the human body to protect itself against dangerous agents including bacteria, viruses, and poisons ...

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07 November 2024

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Chaperone-mediated autophagy: a unique way to enter the lysosome world

Chaperone-mediated autophagy: a unique way to enter the lysosome world Trends Cell Biol. 2012 Aug ;22(8):407 ... characteristics that set CMA apart from other types of lysosomal degradation and the subset of molecules that confer cells the capability to identify individual cytosolic proteins and direct them across the lysosomal membrane for ...

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07 November 2024

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General Principles of Cell Communication

Mechanisms enabling one cell to influence the behavior of another almost certainly existed in the world of unicellular organisms long before multicellular organisms appeared on Earth. Evidence comes from studies of present-day …

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07 November 2024

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CD64 overexpression can protect cell therapeutics from

The new approach to protecting cells from antibody-mediated cellular cytotoxicity (ADCC) relies on the overexpression of the IgG receptor CD64. To overcome this limitation, scientists from the University of California and collaborators have developed a gene engineering approach providing antibody protection for cell therapeutics.

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07 November 2024

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Astrocytic Piezo1-mediated mechanotransduction determines

Astrocytic Piezo1-mediated mechanotransduction determines adult neurogenesis and cognitive functions ... (World Precision Instruments) holding a beveled glass needle with ∼50 mm outer diameter. For injections into adult hippocampus, mice were anesthetized with avertin, head fixed with a stereotaxic frame, and treated with ophthalmic eye ...

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07 November 2024

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Cell-Mediated Immunity (CMI): T Cell Types and …

Cell-mediated immunity (CMI) is a complex series of events that involve the activation of T lymphocytes and the elimination of pathogens. The host immune system activates cell-mediated immunity after exposure to intracellular …

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07 November 2024

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Focal adhesion-mediated cell anchoring and migration: …

Focal adhesion-mediated cell anchorage in vivo. (A) Optic cup morphogenesis in fish (zebrafish and medaka). The basal sides of retinal neuroepithelial cells in the optic vesicle form focal adhesion-like clusters and attach to the ECM. Myosin II-mediated constriction of the basal cell sides indents the epithelium and induces its cup shape-like ...

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07 November 2024

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Nanoparticle-mediated cancer cell therapy: basic science to …

Every sixth person in the world dies due to cancer, making it the second leading severe cause of death after cardiovascular diseases. According to WHO, cancer claimed nearly 10 million deaths in 2020. The most common types of cancers reported have been breast (lung, colon and rectum, prostate cases), skin (non-melanoma) and stomach. In addition to surgery, …

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07 November 2024

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Molecular Mechanisms of Melatonin-Mediated Cell …

Melatonin, an endogenously synthesized indolamine, is a powerful antioxidant exerting beneficial action in many pathological conditions. Melatonin protects from oxidative stress in ischemic/reperfusion injury, neurodegenerative diseases, and aging, decreases inflammation, modulates the immune system, inhibits proliferation, counteracts the Warburg effect, and …

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07 November 2024

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Cell-mediated immunological processes in leprosy

In addition to a specific loss of cell-mediated immune response against Myco. leprae, there is also a non-specific drop in the ability of patients with lepromatous leprosy to show other aspects of cell-mediated immune response, e.g., contact sensitivity and skin homograft rejection.

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07 November 2024

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Material‐mediated cell immobilization technology in the biological

Compared with free-cell fermentation, immobilized cells show strong growth and metabolism performance in complex environments, such as environments with low pH, or with high concentrations of substrate and product. The metabolic properties of immobilized cells mainly depend on the carrier materials.

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07 November 2024

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Cell-Mediated Immunity (CMI): T Cell Types and Functions

Helper T cell (TH): TH cells are also called CD4+ cells, as these cells bear CD4 receptors. Helper T cell lies at the center of adaptive immunity, which coordinates with all other immune mechanisms. It relates to cytotoxic T cells via cytokines, humoral immunity via B cells, and innate immunity via neutrophils and macrophages.

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07 November 2024

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Group 2 Innate Lymphoid Cells Are Critical for the …

Immunity Article Group 2 Innate Lymphoid Cells Are Critical for the Initiation of Adaptive T Helper 2 Cell-Mediated Allergic Lung Inflammation Timotheus Y.F. Halim,1,2,3 Catherine A. Steer,1 Laura Matha¨,1 Matthew J. Gold,4 Itziar Martinez-Gonzalez,1 Kelly M. McNagny,4 Andrew N.J. McKenzie,3 and Fumio Takei1,5,* 1Terry Fox Laboratory, British Columbia Cancer Agency, …

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07 November 2024

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Immunity, Cell Mediated

Immunity, cell mediated The immune system is a network of cells and organs that work together to protect the body from infectious organisms. Many different types of organisms such as bacteria, viruses, fungi, and parasites are capable of entering the human body and causing disease. It is the immune system's job to recognize these agents as foreign and destroy them.

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07 November 2024

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The mechanism of novel potential porphyrin photosensitizer mediated …

However, 2TMeQ[6]-TPPPA was less effective than TPPPA in terms of ROS production capacity and toxicity to SH-SY5Y cells after self-assembling with TMeQ[6]. In conclusion, our study explored that TPPPA can induce ROS overproduction leading to apoptosis, and its mediated photodynamic therapy is a highly effective treatment option for SH-SY5Y cells.

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07 November 2024

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Transplantation of chemically induced pluripotent stem-cell …

Chemically induced stem-cell-derived islets were transplanted beneath the abdominal anterior rectus sheath in one patient with type 1 diabetes, ... Chronic rejection: a significant role for Th17-mediated autoimmune responses to self-antigens. Expert Rev. Clin. Immunol. 2012; 8:663-672. Crossref. Scopus (0) PubMed.

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07 November 2024

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Intracellular zinc protects tumours from T cell-mediated

To further confirm a role for CBFβ in modulating tumour cell sensitivity to both CAR-T cell and TNF-mediated death, we carried out competitive cell death assays by mixing E2-Crimson-labelled sgNT ...

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07 November 2024

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Gap junction‐mediated cell‐cell interaction between …

Our findings indicate that gap junction-mediated cell-cell interaction is one of the major pathways for MSC-mediated suppression of inflammation in the brain following stroke and provides a novel strategy to maintain the blood-brain barrier in injured brain. Furthermore, our current results have the potential to provide a novel insight for ...

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07 November 2024

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Chaperone-mediated autophagy: A unique way to enter the lysosome world

TY - JOUR. T1 - Chaperone-mediated autophagy. T2 - A unique way to enter the lysosome world. AU - Kaushik, Susmita. AU - Cuervo, Ana Maria. N1 - Funding Information: Work in our laboratory is supported by National Institutes of Health (NIH) grants from the National Institute on Aging (NIA), National Institute of Neurological Disorders and Stroke (NINDS), the Beatrice and …

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07 November 2024

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13.51: Cell-Mediated Immune Response

Cell-Mediated Immune Response. In addition to the humoral response, the other type of immune response is the cell-mediated immune response, which involves mainly T cells.It leads to the destruction of cells that are infected …

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07 November 2024

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Molecular Basis for Antibody-Mediated Neutralization of New World …

(Cell Host & Microbe 18, 705–713; December 9, 2015) ... Molecular Basis for Antibody-Mediated Neutralization of New World Hemorrhagic Fever Mammarenaviruses. Selma Mahmutovic. Selma Mahmutovic. Search for articles by this author. Lars Clark.

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07 November 2024

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50.3: Cell-Mediated Immunity

Mucosa-associated lymphoid tissue (MALT), illustrated in Figure 50.3.8 50.3. 8, is a collection of lymphatic tissue that combines with epithelial tissue lining the mucosa throughout the body. This tissue functions as the immune barrier and response in areas of the body with direct contact to the external environment.

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07 November 2024

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13.51: Cell-Mediated Immune Response

Cell-Mediated Immune Response. In addition to the humoral response, the other type of immune response is the cell-mediated immune response, which involves mainly T cells.It leads to the destruction of cells that are infected with …

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07 November 2024

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Cilia as Wnt signaling organelles: Trends in Cell Biology

Wnt signaling and cilia. Cilia are membrane-bound, microtubule-based organelles that play crucial roles in the generation of movement [motile cilia, flagella (see Glossary)] and transduction in cell signaling pathways (primary cilia). Dysfunction in cilium formation or function gives rise to a group of syndromes referred to as ciliopathies [1].

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07 November 2024

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World Journal of Stem Cells

World Journal of Stem Cells. Published by Baishideng Publishing Group Co ... leading to higher cancer stem cell populations and breast cancer progression. miR-140 downregulation is mediated ...

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07 November 2024

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Small world but large differences: cultivar-specific secondary

Tea plant (Camellia sinensis) is an evergreen cash crop in Asia, Africa and Latin America, and China is the largest tea plantation country, with a total plantation area of 3.217 million hm 2 and a total dry tea output of 2.932 million t in 2020, ranking first in the world in both area and output (Cernava et al. 2019; Fan and Han 2020).The number and type of …

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07 November 2024

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Basics of memory B‐cell responses: lessons from and for the real world

The generation of such protective cells and antibodies is mediated by a process of clonal expansion and diversification of fates, followed by a contraction to the essential components of durable immunity. ... particularly in Africa. 68 Over half of the world's population is at risk for malaria, where over 200 million cases of clinical malaria ...

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07 November 2024

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Cytokine-mediated communication: a quantitative appraisal …

Intercellular communication mediated by cytokines is the main mechanism by which cells of the immune system talk to each other. Many aspects of cytokine signalling in the …

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07 November 2024

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CellDialog: A Computational Framework for Ligand-Receptor-Mediated Cell …

Intercellularcommunication significantly influences tumor progression, metastasis, and therapy resistance. An intercellular communication inference method includes two main procedures: ligand-receptor interaction (LRI) curation and LRI-mediated intercellular communication strength measurement. The construction of a comprehensive, high-confident and well-organized LRI …

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07 November 2024

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Mycobacterium tuberculosis: immune response, biomarkers, …

According to the estimation of the World Health Organization (WHO), the number of newly diagnosed TB cases worldwide in 2021 was estimated to be 10.6 million (95% CI: 9.9–11.0 million), ... thereby dampening or enhancing T cell‐mediated immune responses. 198 In …

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